The Science of NMN and NAD+
NAD+-The Key to Longevity
Nicotinamide adenine dinucleotide referred to as NAD +, or Coenzyme I, is one of the most extensive and important biochemical substances naturally found in the human body. NAD+ is responsible for hundreds of metabolic reactions in the human body and participates in nearly 50% of all metabolic activities. Additionally, NAD+ is responsible for the activation of the longevity proteins family (Sirtuins), which are responsible for prolonging lifespan and inhibiting aging in the human body.
The three main physiological functions of NAD + include:
1. Creating more than 95% of energy
NAD + provides 95% of the body's energy through the cellular tricarboxylic acid cycle and fat β oxidation. It plays an essential role in cell energy metabolism, oxidative stress regulation, and signal pathway transmission.
2. Repairing damaged DNA
NAD + is a necessary substrate for DNA repair enzyme PARP, which has a significant impact on DNA repair, gene expression, cell cycle development, cell survival, chromosome reconstruction, and gene stability.
3. Activating longevity proteins-Sirtuins
It activates all 7 longevity proteins (Sirtuins 1-7) in the human body and plays an important role in cell resistance, energy metabolism, prevention of cell mutation, cell apoptosis, and aging.
However, as we age, the level of NAD+ in the human body decreases, leading to a decline in the function of mitochondria, the body's energy "generator". After reaching middle age, the amount of NAD+ in the human body sharply decreases to a fraction of that in young people. This decline triggers a drop in the activity of anti-aging proteins, which leads to aging manifestations such as memory loss, impaired cardiovascular function, decreased immunity, poor sleep quality, energy decline, constipation, hair loss, loss of appetite, etc.
NMN-The most direct and effective way to improve NAD+
NMN (Nicotinamide Mononucleotide/β-Nicotinamide Mononucleotide) is the most direct precursor of NAD +. As a direct precursor, once NMN enters the body it is shorty transformed into NAD+. Like NAD+, NMN is also a substance naturally present in all organisms including the human body and various foods It's just that the content of NMN in food is so small that it cannot be adequately supplemented through daily diet alone. However, through daily oral administration of NMN, humans can increase NAD+ levels , resist aging and bring their bodies back to a "youthful state".
